Clinical information
Drug Monitoring
What Therapeutic Drug Monitoring is and why it matters for patient safety.
What is TDM?
Drug concentration and therapeutic effect
There is a greater correlation between blood drug concentration and its effect than between the administered dose and the effect. This is due to large interindividual variability in drug absorption, distribution, metabolism and excretion.
TDM (Therapeutic Drug Monitoring) aims to dose a drug in a patient so that the resulting concentrations fall within the range characterised by high efficacy and low risk of toxic symptoms — the so-called therapeutic window.
View our servicesWhy it matters
Benefits of TDM in clinical practice
TDM is particularly important for drugs with a narrow therapeutic index, high pharmacokinetic variability, or used in patients with organ dysfunction.
Dosing individualisation
Dose tailored to the specific patient, not to the "average" — lower risk of ineffectiveness or toxicity.
Detection of drug interactions
Full pharmacokinetic profile allows identification of adverse interactions with other concurrently used drugs.
Optimisation in high-risk groups
Children, patients with renal or hepatic insufficiency, transplant recipients — groups where standard dosing often fails.
Rapid clinical response
Results within 48 hours allow ongoing dosage adjustment without therapeutic delays.
Interested in implementing TDM?
Contact us to discuss collaboration details and tailor the scope of testing to your centre's needs.